Fig. 6

A The intersections of different sensitive TI between TCGA-HNSCC, GSE65858, and GSE41613. B–L The median IC50 of different TI in the HHSG and LHSG. The median IC50 was significantly lower for the LHSG than the HHSG for B PF-56227, C Obatoclax Mesylate, D Pyrimethamine, E Rapamycin, G Vinorelbine, H Midostaurin, I JQ12, J FTI-277, K Crizotinib, and L AUY922. The LHSG had a significantly higher median IC50 in the LHSG than the HHSG for (F) Thapsigargin. M Differences in IC gene expression between the HHSG and the LHSG (^nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001). TI targeted inhibitor, TCGA The Cancer Genome Atlas, HNSCC head and neck squamous cell carcinoma, HHSG high hypoxia score group, LHSG low hypoxia score group, IC immune checkpoint