Fig. 3
A The interaction between HRGs in HNSCC. The degree of HRG significance is represented by the size of the circle. B The consensus matrix for all HNSCC samples demonstrated clustering stability. Three subtypes were determined for all samples (k = 3). C OS differences among the three hypoxia clusters A, B, and C. D HRG expressions in the different hypoxia clusters and associated clinical characteristics. E Infiltration of 23 immune cell types. F Association with immune-related functions. G IC expressions in the three hypoxia clusters (nsP > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001). H Activation status of biological behaviors among the three hypoxia clusters. HRGs hypoxia-related genes, HNSCC head and neck squamous cell carcinoma, OS overall survival, IC immune checkpoint, ssGSEA single-sample gene set enrichment analysis, GSVA gene set variation analysis