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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke

Fig. 3

The progression of atherosclerotic plaque is associated with an increased number of active cells in the arterial intima (macrophages and smooth muscle cells) that avidly take up 18F-FDG (SUVmax). Many of these cells become foam cells by taking up atherogenic lipoproteins retained in the intimal extracellular matrix, acquiring a highly proinflammatory phenotype that release cytokine and sLRP1 to the circulation. The results of the present study show the close relationship between sLRP1 and proinflammatory cytokines (sICAM-1, sVCAM-1 and FKN) in the blood, as well as between circulating sLRP1 levels and intra-plaque inflammation measured by PET in patients with a recent ischemic stroke. 18F-FDG 18F-fluorodeoxyglucose, SUVmax standardized uptake value, sLRP1 soluble low-density lipoprotein receptor-related protein 1, sICAM-1 soluble intercellular cell adhesion molecule 1, sVCAM-1 soluble vascular adhesion molecule 1 (sVCAM-1), FKN fractalkine

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