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Fig. 9 | Journal of Translational Medicine

Fig. 9

From: β-glucan protects against necrotizing enterocolitis in mice by inhibiting intestinal inflammation, improving the gut barrier, and modulating gut microbiota

Fig. 9

Summary scheme of the mechanisms underlying the preventive effect of β-glucan on necrotizing enterocolitis. Necrotizing enterocolitis is characterized by disturbed gut microbiota, destroyed gut barrier, activated TLR4, and excessive inflammatory cytokine levels. -glucan suppressed the TLR4-NF-B signaling pathway, and thus decreased inflammatory cytokine levels induced by necrotizing enterocolitis. β-glucan protected intestinal epithelial barrier disruption induced by necrotizing enterocolitis, via up-regulating the tight junction protein expressions, including ZO-1, Occludin, and Claudin-1

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Journal of Translational Medicine

ISSN: 1479-5876

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