Fig. 10
In-silico simulation of the immune response with PspA1-5c+p vaccine. A Diversity of the immunoglobulin production in response to PspA1-5c+p injections (PspA1-5c+p antigen, and IgM, IgG1, and IgG2 subclasses are shown as black and colored peaks, respectively). B Cytokines and interleukin levels. The inset graph shows the level of IL-2 with the Simpson index, D shown by the dotted line, as a measure of diversity and danger signal along with the leukocyte growth factor IL-2. C The evolution of B-cell and plasma cell populations after the three administrations. D The evolution of T-helper, T-cytotoxic cell, and T regulatory cell populations after the injections. The cells not presented with the antigen were defined as being in the resting state, while the anergic state indicates the tolerance of the T-cells to the PspA due to repeated exposure. The evolution of the Natural killer cell population (E), Macrophage population (F), and Dendritic cell population (G)