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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: M2 tumor-associated macrophage mediates the maintenance of stemness to promote cisplatin resistance by secreting TGF-β1 in esophageal squamous cell carcinoma

Fig. 6

Blockade of TGF-βRI in vivo reversed M2-TAMs-mediated cisplatin resistance. A Tumor images of nude mice tumorigenic model injected with shTGFβR1 EC109 cells or shNC EC109 cells mixed with M2-TAM. B The weight of tumor tissue in two groups. C Growth curve of tumor in two groups. D Western blot was used to detect the expression of TGF-β/Smad2/3 pathway protein, stemness markers CD44 and OCT4 in tumor tissues of nude mice. E Immunohistochemistry and HE staining were used to analyze the expression of ki67, TGF-β1, CD44, OCT4, and p-Smad2/3 in two groups of tumor tissues. Scale bar: 100 μm

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Journal of Translational Medicine

ISSN: 1479-5876

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