Fig. 4
From: Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1
Aa-Z2 reprogramed the glucose metabolism by targeting PDK-1 in OS cells. A, B Flow cytometry analysis of JC-1 in Aa-Z2-treated 143B and HOS cells. C, D Detection of ATP, lactic acid and pyruvate in Aa-Z2-treated 143B and HOS cells. E, F Expression of PDK-1 and p-PDH was detected by WB in Aa-Z2-treated 143B and HOS cells. G, H Analysis of the relationship between overall survival and PDK-1 expression in the TCGA and TARGET datasets. Mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)