Table 3 Multivariate analysis of overall survival in the overall population by volume of disease and time of metastatic disease presentation

Subgroup

 LV/PLT

1 (ref.)

 LV/DN

0.59

1.15 (0.69–1.94)

 HV/PLT

0.024

1.90 (1.09–3.32)

 HV/DN

0.005

2.17 (1.26–3.73)

Age

  > 75 vs ≤ 75 years

0.20

1.28 (0.88–1.85)

Gleason score

 8 + vs ≤ 7

0.52

1.13 (0.78–1.65)

ECOG PS

  ≥ 1 vs 0

0.012

1.66 (1.12–2.45)

Treatment for mCSPC

 ADT alone

1 (ref.)

 ADT + D

0.44

0.80 (0.46–1.40)

 ADT + Radiotherapy

0.16

0.42 (0.13–1.41)

PSA

  > 11.4 vs ≤ 11.4 ng/mL

0.001

1.80 (1.27–2.55)

Volume at M1

 HV vs LV

0.77

1.07 (0.69–1.65)