Table 1 Patient characteristics
Variable | Overall series n = 417 No. (%) | LV/PLT n = 157 No. (%) | LV/DN n = 87 No. (%) | HV/PLT n = 64 No. (%) | HV/DN n = 109 No. (%) | p-value* |
|---|---|---|---|---|---|---|
Median age at start of ARSi, yrs (IQR) | 75 (12) | 75 (10) | 75 (10) | 78 (16) | 75 (17) | 0.14 |
Race (NA:4) | ||||||
Caucasian | 373 (90.3) | 147 (94.2) | 78 (90.7) | 59 (92.2) | 89 (83.2) | 0.24 |
Black | 25 (6.1) | 7 (4.5) | 4 (4.7) | 3 (4.7) | 11 (10.3) | |
Hispanic | 12 (2.9) | 2 (1.3) | 3 (3.5) | 2 (3.1) | 5 (4.7) | |
Asian | 3 (0.7) | 0 (0) | 1 (1.1) | 0 (0) | 2 (1.8) | |
Gleason score (NA: 53) | ||||||
≤ 7 | 140 (38.5) | 77 (54.2) | 24 (29.6) | 23 (40.4) | 16 (19.0) | |
8+ | 224 (61.5) | 65 (45.8) | 57 (70.4) | 34 (59.6) | 68 (81.0) | 0.0001 |
Prior local therapy | ||||||
No | 177 (42.4) | 0 (0) | 78 (89.7) | 0 (0) | 99 (90.8) | |
Surgery | 167 (40.0) | 122 (77.7) | 7 (8.0) | 34 (53.1) | 4 (3.7) | |
Radiotherapy | 73 (17.6) | 35 (22.3) | 2 (2.3) | 30 (46.9) | 6 (5.5) | 0.0001 |
Volume at M1 (NA:2) | ||||||
Low | 291 (70.1) | 151 (96.2) | 79 (90.8) | 29 (45.3) | 32 (29.9) | |
High | 124 (29.9) | 6 (3.8) | 8 (9.2) | 35 (54.7) | 75 (70.1) | 0.0001 |
Treatment for mCSPC (NA:47) | ||||||
ADT alone | 308 (83.2) | 120 (97.6) | 66 (77.6) | 48 (90.6) | 74 (67.9) | |
ADT + Docetaxel | 44 (11.9) | 3 (2.4) | 6 (7.1) | 5 (9.4) | 30 (27.5) | |
ADT + Radiotherapy | 18 (4.9) | 0 (0) | 13 (15.3) | 0 (0) | 5 (4.6) | 0.0001 |
ECOG PS at start of ARSi (NA:20) | ||||||
0 | 225 (56.7) | 104 (68.0) | 56 (66.7) | 23 (39.0) | 42 (41.6) | 0.0001 |
≥ 1 | 172 (43.3) | 49 (32.0) | 28 (33.3) | 36 (61.0) | 59 (58.4) | |
Median PSA at start of ARSi (NA:20) | ||||||
ng/mL (IQR) | 11.65 (30.52) | 7.50 (20.34) | 11.90 (28.82) | 17.73 (33.78) | 21.21 (84.26) | 0.001 |
Treatment discontinuation (NA:2) | ||||||
Yes | 48 (11.6) | 20 (12.8) | 11 (12.6) | 8 (12.7) | 9 (8.3) | 0.66 |
No | 367 (88.4) | 136 (87.2) | 76 (87.4) | 55 (87.3) | 100 (91.7) | |
Number of cycles of 1st line ARSi (NA:47) | ||||||
Median (IQR) | 13.7 (23.0) | 19 (27.6) | 19 (23.0) | 9 (15.4) | 11 (16.0) | 0.0001 |
Median FU in overall population, months (95%CI) | 32.5 (30.6–34.2) | 38.3 | 35.1 (31.6–38.6) | 24.8 (20.5–28.5) | 26.3 (23.2–30.4) | 0.0001 |