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Table 4 Characteristics of patients with AHF classified by eGFR levels

From: Plasma GAS6 predicts mortality risk in acute heart failure patients: insights from the DRAGON-HF trial

 

eGFR < 60

P value

eGFR ≥ 60

P value

Death

(n = 108)

Live

(n = 173)

Total

(n = 281)

Death

(n = 85)

Live

(n = 666)

Total

(n = 751)

GAS6, ng/mL

12.5 ± 3.6

10.4 ± 3.5

11.2 ± 3.7

< 0.001

11.8 ± 3.2

9.8 ± 3.4

10.0 ± 3.5

< 0.001

Age, years

77 ± 9

74 ± 12

75 ± 11

0.005

76 ± 11

69 ± 11

70 ± 12

< 0.001

BMI, kg/m2

23.6 ± 3.9

24.2 ± 4.0

24.0 ± 4.0

0.27

23.3 ± 3.5

24.6 ± 3.4

24.5 ± 3.0

0.002

HB, Hg/L

117 ± 22

122 ± 22

120 ± 22

0.07

126 ± 22

132 ± 16

131 ± 17

0.01

BUN, mmol/L

13.1 ± 5.4

10.7 ± 4.9

11.6 ± 5.0

< 0.001

7.3 ± 2.6

6.2 ± 1.8

6.3 ± 2.0

< 0.001

eGFR, mL/min/1.73m2

42 (27–51)

47 (37–54)

45 (35–53)

0.017

78 (66–93)

88 (74–104)

87 (73–102)

< 0.001

TnT, ng/mL

0.084 (0.043–0.420)

0.039 (0.023–0.082)

0.022 (0.013–0.059)

< 0.001

0.039 (0.019–0.261)

0.021 (0.013–0.057)

0.022 (0.013–0.059)

0.002

CRP, mg/L

7.8 (3.2–27.4)

5.0(3.0–17.1)

6.1(3.0–19.2)

0.053

3.5 (3.0–10.8)

3.2 (3.0–9.0)

3.2 (3.0–9.0)

0.806

NT-proBNP, pg/mL

7482 (3516–18,315)

2510 (912–5743)

3674 (1459–8946)

< 0.001

2436 (849–5182)

1083 (524–2272)

1163 (543–2527)

< 0.001

LVEF, %

40 ± 14

48 ± 14

45 ± 14

< 0.001

44 ± 13

48 ± 13

48 ± 13

0.006

LVMI, mm

129 ± 45

120 ± 37

123 ± 40

0.12

116 ± 42

111 ± 34

111 ± 35

0.286

  1. GAS6: growth arrest specific 6; BMI: body mass index; Hb: hemoglobin; BUN: blood urea nitrogen; eGFR: estimate glomerular filtration rate; TnT: troponin T; CRP: C-reactive protein; NT-proBNP: N-terminal pro-B-type natriuretic peptide; LVEF: left ventricular ejection fraction; LVMI: left ventricular mass index. Death refers to all-cause death