Fig. 3

CCCs modulates the features of myeloid cells. A t-SNE plot depicting the myeloid cell subpopulations’ annotation. B, C Monocle analysis of myeloid cell subtypes, and the cells were ordered by pseudotime. D, E CCCs between main cell types of myeloid cells, tumor clusters by CellChat analysis based on interaction strength and numbers. F Trajectory Analysis suggests the role of CCCs molecules in process of myeloid differentiation. G Heatmap reveals the correlation between expression levels of CCCs molecules and relative abundance of immune cells, Welch’s t test: *P < 0.05; **P < 0.01; ***P < 0.001