Skip to main content
Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Cell–cell communications shape tumor microenvironment and predict clinical outcomes in clear cell renal carcinoma

Fig. 2

Cell–cell communications (CCCs) referenced by CellChat demonstrated notable alterations in receptors-ligands-mediated communications between VHL-wild and VHL-mutated cells in ccRCC. A Circle plots depicting the interaction numbers and interaction strength between VHL-wild and VHL-mutated cells. Blue lines indicate that the displayed communication is decreased in VHL-mutated cells, while red lines indicate that communication is increased in VHL-mutated cells compared with non-VHL group. The arrows indicate the direction of intercellular communication, which were also marked on the right in black for annotation. B NMF clusters based on the communication patterns of different cell components and types of ligands/receptors in VHL-wild group and C VHL-mutated group, The closer the color to red indicates the more contribution of the cell group or signaling pathway to each latent pattern. D scatter plot showing the intensity of the outgoing and incoming interactions in two-dimensional manifold. The size of the circles suggests the numbers of significantly expressed receptor-ligand pathways of different cell populations. E Based on the pairwise Euclidean distance in the shared two-dimensional manifold, we ranked the intersecting signaling pathways of VHL-wild and VHL-mutated groups. The length of the grey rectangle presents a difference in this pathway between the VHL-mutated and VHL-wild groups F The vertical axis is the cell that sends or receives the signal, and the horizontal axis is the pathway that receives or sends the signal. The color of the heat map represents the strength of the signal. The pillars on the upper and right sides are the accumulation of the strength of the vertical axis and the horizontal axis. G Comparison of Integral signal with superimposed input and output signals between VHL-wild and VHL-mutated groups, dot color reflects communication probabilities and dot size represents computed p-values computed from one-sided permutation test. Empty space means the communication probability is zero

Back to article page