The epigenetic factor CHD4 contributes to metastasis by regulating the EZH2/β-catenin axis and acts as a therapeutic target in ovarian cancer

Table 1 The pathways positively correlated with CHD4 in TCGA were analysed by gene set enrichment analysis

Signaling name	Size	NES	NOM p-val	FDR q-val	FWER p-val	Rank at max
NOTCH_SIGNALING_PATHWAY	47	2.101641	0	0.010654	0.006	11,320
INOSITOL_PHOSPHATE_METABOLISM	54	2.050652	0	0.016514	0.016	15,207
BASAL_CELL_CARCINOMA	55	2.034353	0	0.012997	0.018	10,713
ADHERENS_JUNCTION	73	2.017389	0.002004	0.012376	0.028	9599
PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	76	1.979099	0.001992	0.015025	0.039	15,207
WNT_SIGNALING_PATHWAY	150	1.978311	0.002037	0.012521	0.039	12,401
TASTE_TRANSDUCTION	51	1.940397	0	0.017843	0.054	16,175
HEDGEHOG_SIGNALING_PATHWAY	56	1.872574	0.00404	0.039105	0.13	12,001
LYSINE_DEGRADATION	44	1.855039	0.003937	0.042479	0.154	13,292
MELANOGENESIS	101	1.838217	0.006	0.047405	0.184	16,175
ERBB_SIGNALING_PATHWAY	87	1.809339	0.005882	0.057518	0.222	16,540
COLORECTAL_CANCER	62	1.807526	0.008032	0.053987	0.227	10,941
ENDOMETRIAL_CANCER	52	1.803657	0.008032	0.051899	0.231	10,941
THYROID_CANCER	29	1.756727	0.008163	0.076846	0.313	14,471
PROSTATE_CANCER	89	1.753645	0.010225	0.0733	0.316	11,645
GNRH_SIGNALING_PATHWAY	101	1.749633	0.006061	0.070386	0.32	16,894
AXON_GUIDANCE	129	1.739887	0.014028	0.072038	0.339	16,047
SPLICEOSOME	127	1.727772	0.022	0.075285	0.356	6232
UBIQUITIN_MEDIATED_PROTEOLYSIS	134	1.722847	0.01222	0.074673	0.369	12,985

ISSN: 1479-5876