Fig. 5

The downstream molecule of CHD4 is EZH2. A The relationship of the expression levels of DNMT1, DNMT3b, EZH2 and G9a with the prognosis of patients with ovarian cancer. B Analysis of the correlation of CHD4 with EZH2 and DNMT3b at the mRNA expression level. C There was a positive correlation between CHD4 and EZH2 at theprotein level (p < 0.0001). D Downregulation of CHD4 in ovarian cancer cells resulted in decreased EZH2 expression. E Western blot analysis showed that inhibition of EZH2 expression had no effect on the expression level of CHD4