Fig. 4

Therapeutic effect of CHD4 inhibitor on ovarian cancer in vivo. A The administration mode diagram: ovarian cancer cells and Matrigel were mixed at a ratio of 1:1 and injected intraperitoneally into mice. The growth of the tumour was observed by an in vivo imaging instrument on the 10th day after injection, and then different drugs were administered on the 1st, 4th, 7th, 11th, 14th and 17th days. The control group was given 0.1% DMSO, the low-dose group was given 1 mg/kg romidepsin, and the high-dose group was given 2 mg/kg romidepsin. Imaging was performed every 10 days to observe the growth of the tumour. B Bioluminescence imaging of tumour bearing nude mice after treatment with 0.1% DMSO, low-dose romidepsin, and high-dose romidepsin. C The weights of nude mice in the romidepsin treatment group was higher than that in the DMSO control group. D The number of liver metastases in nude mice in the high-dose romidepsin treatment group was significantly less than that in the DMSO control group. **p < 0.01