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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer

Fig. 5

Knockdown of miR-140-3p partially reverses the inhibitory effect of circ_0001789 silencing. A Reverse transcription-quantitative PCR was used to detect the expression of miR-140-3p in AGS cells, while HGC27 cells were transfected with NC inhibitor or miR-140-3p inhibitor. B Cell Counting Kit-8 proliferation assay in AGS and HGC27 cells subjected to different treatments (sh-NC, sh-circ_0001789 or sh-circ_0001789 + miR-140-3p inhibitor). C and D Cell migration and invasion assays in AGS and HGC27 subjected to different treatments (sh-NC, sh-circ_0001789 or sh-circ_0001789 + miR-140-3p inhibitor). E Tube formation assay in human umbilical vein endothelial cells incubated with exosome samples from AGS and HGC27 cells exposed to different treatments (sh-NC, sh-circ_0001789 or sh-circ_0001789 + miR-140-3p inhibitor). F Protein levels of E-cadherin, N-cadherin, vimentin and VEGF-A in AGS and HGC27 cells subjected to different treatments (sh-NC, sh-circ_0001789 or sh-circ_0001789 + miR-140-3p inhibitor). *P < 0.05, **P < 0.01, ***P < 0.001. miR, microRNA; circ, circular RNA; sh, small hairpin; NC, negative control

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