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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway

Fig. 4

Knockdown of cNDC80 inhibits GBM growth in vivo. A–C After stereotaxic orthotopic implantation of glioma cells weekly, bioluminescent pictures of the intracerebral tumors of nude mice (10 mice per group) were obtained. D Kaplan–Meier survival analysis revealed that mice in the shcNDC80 group outlived those in the shCONT group. E The tumor volume of the shcNDC80 group was dramatically decreased, according to HE histology. F Tumors grown as xenografts in the shCONT and shcNDC80 groups were analyzed using immunohistochemistry. Scale bar 100um. Each experiment was conducted three times, and the findings are shown as mean ± SD. (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)

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