Skip to main content

Table 1 Effects of biologically active factors on EC

From: Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer

Biologically active factors

Roles in EC

References

Leptin

Involving in insulin resistance

[44]

Resistin

Involving in insulin resistance

[46]

Visfatin

Activation of insulin receptor and its substrate IRS1/2 to promote proliferation and inhibit apoptosis of EC cells through PI3K/Akt and MAPK/ERK pathways

[52]

Insulin

Promoting EC cells proliferation and invasion, inhibiting apoptosis through PI3K/Akt and MEK/ERK pathway;

Synergizing with estrogen to promote type 1 EC progression through activating ER-α and InsR-β respectively;

Promoting EC progression through upregulation of TET1-driven GPER expression

[60, 61]

[58, 62]

[63]

Adiponectin

Protecting against EC through insulin sensitizing

[44, 47]

Vaspin

Protecting against EC through insulin sensitizing

[44, 47]