Hyperuricemia as an effect modifier of the association between metabolic phenotypes and nonalcoholic fatty liver disease in Chinese population

Table 2 Odds ratios (ORs) and 95% confidence intervals (CIs) of nonalcoholic fatty liver disease in relation to body mass index (BMI) and metabolic-related factors

	Subjects	Un-adjusted OR (95%CI)	Basic adjusted^a OR (95%CI)	Muti-adjusted^b OR (95%CI)
BMI
< 24	1147	Reference	Reference	Reference
24–28	1323	4.62 (3.83–5.57)	4.34 (3.59–5.25)	3.06 (2.49–3.78)
≥ 28	489	16.81 (12.93–21.86)	15.76 (12.06–20.59)	7.96 (5.92–10.70)
P_trend		< 0.001	< 0.001	< 0.001
Metabolic-related factors^c
0	721	Reference	Reference	Reference
1	992	2.72 (2.14–3.44)	2.82 (2.21–3.61)	1.81 (1.38–2.38)
2	744	6.13 (4.80–7.84)	6.8 (5.29–8.96)	3.50 (2.62–4.69)
3	410	11.91 (8.92–15.90)	14.36 (10.56–19.52)	5.71 (4.06–8.04)
4	92	22.78 (12.98–39.97)	31.70 (17.75–56.62)	11.77 (6.31–21.94)
P_trend		< 0.001	< 0.001	< 0.001

^aAdjusted for age, and sex
^bAdjusted for age, sex, alanine transaminase, total bilirubin, albumin, creatinine, and uric acid, and BMI, and metabolic-related factors if application
^cMetabolic-related factors refer to four metabolically unhealthy statuses, i.e., high triglycerides (≥ 1.7 mmol/L), elevated SBP (≥ 130 mmHg) or DBP (≥ 85 mmHg), high FBG (≥ 5.6 mmol/L), and low HDL-C (< 1.04 mmol/L for men and < 1.29 mmol/L for women). 0 represent participants who had no metabolically unhealthy status; 1 represent participants who had anyone metabolically unhealthy status; 2 represent participants who had any two metabolically unhealthy status; 3 represent participants who had any three metabolically unhealthy status; 4 represent participants who had four metabolically unhealthy status

ISSN: 1479-5876