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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Concept and application of the probability of pharmacological success (PoPS) as a decision tool in drug development: a position paper

Fig. 1

Guide for estimating PoPS (Probability of Pharmacological Success). Once the key pharmacology and safety endpoints are chosen, exposure–response models are developed with estimation uncertainty and between-subject variability for key parameters. Accounting for any translation uncertainty, the models are used to simulate virtual populations. Given the success criteria and their uncertainty, the simulated populations are used to compute PoPS

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