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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinoma

Fig. 4

SAMHD1 regulation of TBK1-IRF3-IFN-I pathway was IFI16 and STING dependent. A, B The effects of siSAMHD1, siIFI16 or their combination on TBK1-IRF3 pathway in H1299 and H1975 cells were evaluated by immunoblotting. C, D The mRNA levels of IFI16, IFNβ, CCL5 and CXCL10 were detected by qPCR after transfecting siSAMHD1, siIFI16 or combination in H1299 and H1975 cells. E The effects of siSAMHD1, siSTING or their combination on TBK1-IRF3 pathway in H1299 cells were evaluated by immunoblotting. F The mRNA levels of SAMHD1, STING and IFNβ in H1299 cells were detected by qPCR after transfecting siSAMHD1, siSTING or combination. N = 3; *, P < 0.05; **, P < 0.01; ***, P < 0.001

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Journal of Translational Medicine

ISSN: 1479-5876

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