Skip to main content
Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Angiotensin-(1–7) ameliorates sepsis-induced cardiomyopathy by alleviating inflammatory response and mitochondrial damage through the NF-κB and MAPK pathways

Fig. 4

Ang-(1–7) maintains the mitochondrial dynamic equilibrium of cardiomyocytes in SIC mice, reverses their structural dysfunction and damage, and alleviates cardiomyocyte apoptosis. A Representative TEM image of myocardial mitochondria. B Flameng score of TEM images of mitochondria of cardiomyocytes (n = 4). C MMP in myocardial tissue specimens of mice was detected using JC-1 staining (n = 4). D Mitochondrial ATP concentration in myocardial tissues (n = 4). E TUNEL staining images of the myocardial cellular apoptosis (× 200, scale bar: 50 μm). F No. of TUNEL positive cells (n = 4). G Western blot images of Bcl-2, cleaved-caspase-3, Bax, Drp1, Mfn2, and caspase-9 in myocardial tissues. (HM) Quantification of the caspase-9, Drp1, cleaved-caspase-3, Bcl -2, Mfn2, and Bax proteins concentrations in myocardial specimens (n = 4). *p < 0.05, **p < 0.01, ***p < 0.001

Back to article page