Table 3 Statistically significant (independent sample t test, p < 0.05) histogram parameters of ADC, D, D*, f and D*.f among good-response and poor-response groups at baseline (time-points t0) and after 1st cycle of chemotherapy (time-point t1) and their ROC curve analysis for predicting poor-response to chemotherapy
Time-point | Parameters | t test, p value | Sensitivity (%) | Specificity (%) | Cut-off Value | AUC (95% CI) |
|---|---|---|---|---|---|---|
t0 | ADC-Mean | 0.36 | 55 | 67 | > 1.36 | 0.61 (0.42–0.80) |
D-Mean | 0.20 | 65 | 67 | > 1.2 | 0.66 (0.47–0.85) | |
D*-Mean | 0.04 | 65 | 75 | > 26.9 | 0.70 (0.52–0.87) | |
f-Mean | 0.47 | 75 | 50 | > 12.04 | 0.57 (0.37–0.77) | |
D*.f-Mean | 0.13 | 65 | 67 | > 3.95 | 0.67 (0.48–0.86) | |
Mean ADC, D, D*, f, D*.f combined |  | 77 | 77 | < 0.58 | 0.77 (0.62–0.93) | |
D*-skewness | 0.04 | 71 | 67 | < 0.27 | 0.7 (0.52–0.88) | |
D*-entropy | 0.04 | 68 | 69 | > 8.72 | 0.7 (0.52–0.88) | |
D*-90th percentile | 0.03 | 77 | 62 | > 64.68 | 0.72 (0.54–0.9) | |
D*-75th percentile | 0.04 | 76 | 57 | > 36.05 | 0.7 (0.52–0.88) | |
f-entropy | 0.04 | 77 | 62 | > 8.77 | 0.65 (0.46–0.85) | |
D*.f-entropy | 0.03 | 68 | 69 | > 7.1 | 0.72 (0.53–0.9) | |
All Combined |  | 86 | 77 | < 0.66 | 0.87 (0.68–0.99) | |
t1 | ADC-mean | 0.04 | 60 | 77 | > 1.72 | 0.71 (0.57–0.9) |
D-mean | 0.02 | 68 | 70 | > 1.62 | 0.73 (0.54–0.89) | |
D*-mean | 0.13 | 64 | 77 | > 21.33 | 0.65 (0.46–0.83) | |
f-mean | 0.59 | 60 | 58 | > 12.32 | 0.61 (0.42–0.80) | |
D*.f-mean | 0.01 | 77 | 77 | > 3.14 | 0.76 (0.59–0.92) | |
Mean ADC, D, D*, f, D*.f combined |  | 91 | 85 | > 0.55 | 0.92 (0.82–1) | |
ADC-90th percentile | 0.03 | 68 | 77 | > 2.26 | 0.72 (0.54–0.89) | |
D-90th percentile | 0.01 | 73 | 85 | > 2.17 | 0.76 (0.59–0.92) | |
D-75th percentile | 0.03 | 64 | 77 | > 1.94 | 0.72 (0.56–0.89) | |
D-60th percentile | 0.04 | 64 | 62 | > 1.77 | 0.70 (0.53–0.88) | |
D-50th percentile | 0.04 | 55 | 62 | > 1.68 | 0.70 (0.53–0.88) | |
D-25th percentile | 0.03 | 55 | 69 | > 1.36 | 0.71 (0.53–0.89) | |
All Combined |  | 86 | 100 | > 0.60 | 0.96 (0.89–1) |