Table 2 Average Apparent Diffusion Coefficient (ADC), Diffusion coefficient (D), Perfusion Coefficient (D*), Perfusion fraction (f) and D*.f in good-response (GR) and poor-response (PR) groups at baseline (t0), after 1st cycle of chemotherapy (t1), and after 3rd cycle of chemotherapy (t2) and the relative percentage changes of parameters across time-points t0 & t1 (ΔI) and t0 & t2 (ΔII)
Parameters | GR (n = 13) | PR (n = 22) | p-value |
|---|---|---|---|
Time-point t0 | |||
 ADC (× 10−3 mm2/s) | 1.30 ± 0.29*# | 1.41 ± 0.36*# | 0.36 |
 D (× 10−3 mm2/s) | 1.21 ± 0.28*# | 1.35 ± 0.32*# | 0.20 |
 D* (× 10−3 mm2/s) | 23.76 ± 7.56# | 30.95 ± 10.80# | 0.04 |
 f (%) | 13.31 ± 2.68 | 14.05 ± 2.99 | 0.47 |
 D*.f × 10−3 mm2/s | 3.85 ± 1.90# | 5.12 ± 2.52# | 0.13 |
Time-point t1 | |||
 ADC (× 10−3 mm2/s) | 1.53 ± 0.28* | 1.68 ± 0.29* | 0.04 |
 D (× 10−3mm2/s) | 1.44 ± 0.35* | 1.66 ± 0.27* | 0.02 |
 D* (× 10−3mm2/s) | 19.77 ± 4.20 | 25.32 ± 12.47 | 0.13 |
 f (%) | 13.36 ± 2.04 | 12.89 ± 2.69 | 0.59 |
 D*.f (× 10−3mm2/s) | 2.97 ± 1.02 | 4.49 ± 2.32 | 0.01 |
 ADC-ΔI (%) | 20.08 ± 20.24 | 29.00 ± 31.17 | 0.36 |
 D-ΔI (%) | 21.63 ± 27.15 | 28.68 ± 28.12 | 0.47 |
 D*-ΔI (%) | − 14.86 ± 26.63 | − 10.45 ± 50.66 | 0.63 |
 f-ΔI (%) | 3.15 ± 20.28 | − 5.56 ± 21.42 | 0.24 |
 D*.f-ΔI (%) | − 12.12 ± 34.90 | − 4.90 ± 39.22 | 0.59 |
Time-point t2 | |||
 ADC (× 10−3 mm2/s) | 1.66 ± 0.21# | 1.75 ± 0.30# | 0.35 |
 D (× 10−3 mm2/s) | 1.57 ± 0.20# | 1.66 ± 0.27# | 0.29 |
 D* (× 10−3 mm2/s) | 17.77 ± 6.02# | 23.44 ± 10.65# | 0.09 |
 f (%) | 12.55 ± 1.24 | 13.22 ± 2.54 | 0.38 |
 D*.f (× 10−3 mm2/s) | 2.53 ± 1.37# | 3.50 ± 1.86# | 0.11 |
 ADC-ΔII (%) | 31.35 ± 21.99 | 30.01 ± 33.74 | 0.90 |
 D-ΔII (%) | 33.08 ± 18.73 | 27.60 ± 29.48 | 0.55 |
 D*-ΔII (%) | − 22.12 ± 29.97 | − 19.98 ± 31.83 | 0.79 |
 f-ΔII (%) | − 2.16 ± 21.90 | − 2.74 ± 23.86 | 0.94 |
 D*.f-ΔII (%) | − 26.64 ± 49.64 | − 23.73 ± 30.44 | 0.83 |