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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy

Fig. 6

ALA upregulated Parkin/LC3B-mediated mitophagy to repress lung fibroblast activation. AC Protein levels of LC3BII in cell lysate and mitochondrial components. DF Collagen I and α-SMA were assessed after treatment with 3MA (10 μmol/L), parkin siRNA, or Mdivi-1 (10 μmol/L). Data are presented as mean ± SEM. *P < 0.05 versus control group; #P < 0.05 versus TGF-β1 group; P < 0.05 versus TGFβ1 + ALA group; &P < 0.05 versus TGFβ1 + ALA + bafilomycin A1 group (n = 3)

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