Table 3 ER stress sensors or signals triggering MDSC activation were investigated as therapeutic targets
| Â | Diseases | ER stress sensors or signaling | Therapeutic targets or molecules | Types of activated MDSCs | MDSCs phenotype | Species | References |
|---|---|---|---|---|---|---|---|
Cancer | Lung metastasis of breast cancer | ERK/AKT/STAT3 | Periostin | MDSCs | a, b | Murine | [73] |
Lung carcinoma/lymphoma | IRE1É‘/ATF6 | Blockade of the ER stress response | PMN-MDSCs | a, b | Murine | [87] | |
Lung carcinoma/ovarian carcinoma | PERK/NRF2/STING | PERK | MDSCs | a, b, c, d | Human/Murine | [91] | |
Non small cell lung cancer/TB | XBP1/CHOP/PERK/DR5/TRAIL-Rs | TRAIL-Rs | MDSCs | a, b, d | Human/Murine | [12] | |
Mice injected with 3LL lung carcinoma | CHOP/C/EBPβ, IL-6/p-STAT3 | Chop | MDSC | CD11b+ Gr1+ | Murine | [8] | |
Triple-negative breast cancer | IRE1α/XBP1s | IRE1α kinase inhibitor | Cancer-associated fibroblasts | FAP | Murine | [72] | |
HER2/CT26-bearing mice | ARG1/iNOS/NOX2 | 4-PBA | Ly6G + CD11b+ myeloid cells | Ly6G+CD11b+ | Murine | [99] | |
Ovarian carcinoma | IRE-1α/XBP-1 | Targeting the ER stress response | Tumor-infiltrating DCs | Human (CD45+CD3− CD20−CD11c+DEC205+) Murine (CD45+CD11c+CD11b+MHC-II+CD8alow) | Human/Murine | [3] | |
Hepatocellular carcinoma | sXBP1/ATF3/CHOP/ROS/Arg I | LOX-1 + CD15 + PMN-MDSC | LOX-1 + CD15+ PMN-MDSC | LOX-1+CD15+PMN-MDSCs | Human | [86] | |
T lymphocytes-based cancer | Ceramide/Cathepsin B/Cathepsin D/autophagy/ER stress/MDSC apoptosis- and necroptosis | LCL521 | MDSCs | CD11b+ Gr1+ | Murine | [103] | |
prostate cancer | XBP1/Arg1/Nos2 | XBP1 | MDSC | c, d | Human | [89] | |
Colitis and colorectal carcinogenesis | GM-CSF/M-CSF/IL-6/TNF-α/NF-κB/IL-6/STAT3 | Naringin | MDSCs/tumor associated macrophages | a,b CD11b+F4/80 | Murine | [70] | |
Melanoma | XBP1/cholesterol | XBP1 | MDSCs | CD11b+ Gr1+ | Murine | [104] | |
Infection and Inflammatory Disease | Nasopharyngeal carcinoma with Chronic hepatitis B | ER stress/ROS | NOX2 | LOX-1+ PMN-MDSCs | LOX-1+CD15+ | Human | [77] |
Inflammatory bowel disease (IBD) | NOD2/ATG16L1/NALP3/chemokine (C-C motif) receptor 6 | ER stress | MDSCs | c, d | Human | [102] | |
Colitis | NF-κB/IL-6/STAT3 | Myricetin 10 | MDSCs | a,b | Murine | [66] | |
TB and leprosy | IL-1α/IL-6/IFN-I/ATF6/IRE1/XBP1/PERK/ATF4 | UPR elements of ER stress | MDSCs | c, d | Human | [92] | |
leprosy | OLR1/XBP1/ATF4/ATF3/ERN1/IL-10 | Recombinant IFN-γ | MDSC | HLA-DR-CD33+CD15+ | Human | [54] |