Table1 Univariate and Multivariate Analysis of Overall Survival in AML with Normal Karyotype
characteristics | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |
SMIM3 | 2.19(1.19–4.01) | 0.011 | 2.9 (1.51–5.57) | 0.001 |
Age | 2.07(1.11–3.85) | 0.022 | 1.58 (0.82–3.02) | 0.171 |
Sex | 0.65(0.37–1.14) | 0.132 | 0.74 (0.41–1.32) | 0.308 |
WBC, × 109/L | 0.81(0.47–1.41) | 0.464 | NA | NA |
PLT, × 109/L | 1.91(1.09–3.33) | 0.023 | 1.56(0.81–2.98) | 0.18 |
LDH U/L | 1.39(0.78–2.49) | 0.264 | NA | NA |
PB(%) | 0.56 (0.28–1.09) | 0.087 | 0.94(0.43–2.08) | 0.884 |
FLT3 | 1.09(0.6–1.96) | 0.784 | NA | NA |
FLT3-ITD | 1.13(0.63–2.04) | 0.678 | NA | NA |
FLT3-TKD | 0(0-Inf) | 0.997 | NA | NA |
RUNX1 | 2.39(0.73–7.79) | 0.148 | 1.56(0.45–5.49) | 0.485 |
ASXL1 | 1.03(0.54–1.96) | 0.94 | NA | NA |
CBFβ | NA | NA | NA | NA |
CBL | 2.2(0.53–9.12) | 0.278 | NA | NA |
CEBPA | 0.67(0.35–1.27) | 0.221 | NA | NA |
DNMT3A | 0.93(0.47–1.86) | 0.835 | NA | NA |
ETO | NA | NA | NA | NA |
ETV6 | 0.64(0.09–4.66) | 0.662 | NA | NA |
EZH2 | 0(0-Inf) | 0.996 | NA | NA |
IDH1 | 0.68(0.24–1.89) | 0.459 | NA | NA |
IDH2 | 0.47(0.12–1.95) | 0.302 | NA | NA |
JAK2 | 0(0-Inf) | 0.996 | NA | NA |
KIT | 0(0-Inf) | 0.996 | NA | NA |
MLL | 2.65(0.36–19.52) | 0.339 | NA | NA |
NPM1 | 1.12(0.61–2.08) | 0.708 | NA | NA |
NRAS | 0.68(0.29–1.58) | 0.367 | NA | NA |
PHF6 | 1.39(0.19–10.19) | 0.745 | NA | NA |
SETBP1 | 1.77(0.43–7.3) | 0.431 | NA | NA |
SF3B1 | NA | NA | NA | NA |
SRSF2 | 1.16(0.28–4.8) | 0.842 | NA | NA |
TET2 | 0.72(0.42–1.24) | 0.235 | NA | NA |
TP53 | 0(0-Inf) | 0.996 | NA | NA |
U2AF1 | 1.08(0.46–2.53) | 0.857 | NA | NA |
WT1 | 0.92(0.52–1.63) | 0.855 | NA | NA |
ZRSR2 | NA | NA | NA | NA |
Risk | 1.15(0.79–1.67) | 0.476 | NA | NA |
Transplant | 0.23(0.08–0.64) | 0.005 | 0.26(0.09–0.76) | 0.014 |