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Table 1 Comparisons of demographic and clinical characteristics between recipients with AMR and controls

From: Integrative metagenomic and metabolomic analyses reveal the role of gut microbiota in antibody-mediated renal allograft rejection

Variable

AMR (n = 28)

Ctrl (n = 32)

P value

Age, years

33.29 ± 7.154

37.31 ± 8.525

NS

Male gender, n (%)

25 (89%)

26 (81%)

NS

BMI

21.8 (19.7, 25.53)

23.3 (21.1, 24.95)

NS

Cr, μmol/L

285 (218.3, 417.3)

93.5 (75.25, 100.8)

< 0.0001

BUN, mmol/L

16.6 (12.35, 19.4)

6.625 (5.628, 7.413)

< 0.0001

UA, μmol/L

398.5 (316.3, 458.8)

337.5 (301, 370)

0.0198

CO2, mmol/L

21 (18.25, 23)

23.4 (22.05, 25)

0.0019

CysC, mg/L

3.49 (2.78, 4.25)

1.085 (0.975, 1.36)

< 0.0001

ALB, g/L

37.8 (36.15, 39.63)

39.63 (41.45, 48.28)

< 0.0001

TBA, μmol/L

2.75 (2.125, 5.975)

4.65 (3.4, 6.85)

0.0257

LDH, U/L

248.5 (186.8, 327.5)

221 (173.8, 277.5)

NS

ALP, U/L

96 (59.25, 134.3)

77 (70.25, 101)

NS

HGB, g/L

95 (86, 105.5)

139.5 (126.3, 152.5)

< 0.0001

WBC, × 109/L

4.28 (3.523, 6.5)

5.55 (5.01, 6.793)

0.0091

PLT, × 109/L

172 (116.3, 232)

193 (140, 225.8)

NS

CRP, mg/L

1.9 (1.15, 9.41)

0.79 (0.5, 1.755)

0.0005

U-protein, −/±/+/++/+++

0/0/5/9/14

24/4/3/1/0

< 0.0001

Induction therapy, Thymoglobuline, n (%)

28 (100%)

32 (100%)

NS

Maintenance Therapy

   

Tacrolimus, n (%)

28 (100%)

32 (100%)

NS

Mycophenolate mofetil, n (%)

28 (100%)

32 (100%)

NS

Prednisone, n (%)

28 (100%)

32 (100%)

NS

  1. Data for age were expressed as mean ± standard deviation and other continuous variables were expressed as median (interquartile range), while categorical variables were reported as counts. Ctrl: control; AMR: antibody-mediated rejection; BMI: body mass index; Cr: creatinine, BUN: blood urea nitrogen; UA: uric acid; CO2: carbon dioxide; CysC: serum cystatin C; ALB: albumin; TBA: total bile acid; LDH: lactate dehydrogenase; ALP: alkaline phosphatase; HGB: hemoglobin; WBC: white blood cell; PLT: platelet; CRP: C-reaction protein; U-protein: urine protein; NS: not significant (P > 0.05)