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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: MTAP loss: a possible therapeutic approach for glioblastoma

Fig. 1

MTAP metabolism pathway. MTAP metabolizes MTA to produce adenine and methionine utilizing a series of intermediate steps. Loss of MTAP (shown by a bold red cross) results in accumulation of MTA and this inhibits PRMT5. Methionine which gets salvaged by MTAP and also can be generated by the folate metabolism pathway is the core of the salvage pathway and the recycle pathway. Methionine gets converted to SAM by MAT2A and SAM can be converted to either MTA or SAH resulting in the salvage and the recycle pathway respectively. AG-270 inhibits MAT2A and this results in lower levels of SAM and thus slows the growth of tumor cells. MTAP is a significant metabolic enzyme because of its involvement in multiple important cellular processes such as protein synthesis, purine synthesis among others as shown in blue. Single step conversions are shown as solid arrows and conversions requiring multiple steps are shown as dashed arrows

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