Fig. 5

Pladienolide B treatment reverses the induction of PHF5A overexpression on the progression of GC cells. A–D PHF5A overexpressed cells were treated with Pladienolide B to detect changes in cell viability, apoptosis, and migration. Notably, for Figure D, H is the migration time of the cell. The presented results were representative of experiments repeated at least three times. Data was represented as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001. E–G PHF5A overexpression and control MGC-803 cells were subcutaneous injected into nude mice followed by intravenous Pladienolide B treatment to observed tumor volume, tumor size and immunohistochemical staining. Data was represented as mean ± SD (n = 5). *P < 0.05, **P < 0.01, ***P < 0.001