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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma

Fig. 5

The potential molecular mechanisms of correlation between rs11130424 and efficacy after radiotherapy. Rs11130424 implicated expression of CACNA2D3, which regulates PI3K/AKT and Ras/MARK pathways. In addition, 3D chromatin interaction indicated that they interacted with CCDC66, which regulate tumor proliferation, metastasis, angiogenesis and apoptosis. PI3K phosphatidylinositol 3-kinase; MEK: kinse-ERK kinase, ERK extracellular signal-regulated kinase, MARK mitogen-activated protein kinase, caspase 8 apoptosis-related cysteine peptidase 8, caspase 3 apoptosis-related cysteine peptidase 3

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