Fig. 5From: A two-stage genome-wide association study identifies novel germline genetic variations in CACNA2D3 associated with radiotherapy response in nasopharyngeal carcinoma The potential molecular mechanisms of correlation between rs11130424 and efficacy after radiotherapy. Rs11130424 implicated expression of CACNA2D3, which regulates PI3K/AKT and Ras/MARK pathways. In addition, 3D chromatin interaction indicated that they interacted with CCDC66, which regulate tumor proliferation, metastasis, angiogenesis and apoptosis. PI3K phosphatidylinositol 3-kinase; MEK: kinse-ERK kinase, ERK extracellular signal-regulated kinase, MARKÂ mitogen-activated protein kinase, caspase 8Â apoptosis-related cysteine peptidase 8, caspase 3Â apoptosis-related cysteine peptidase 3Back to article page