Genome-wide associated variants of subclinical atherosclerosis among young people with HIV and gene-environment interactions

Table 2 Association of SNPs with cIMT among PWH in different groups

SNP	CHR	Position (GRCh37)	Gene	Location	MAF	Minor allele	Major allele	β value^a	Adjusted P value^a
All PWH
rs6772280	3	156,162,567	KCNAB1	Intronic	0.109	G	A	0.07	3.66E−06
rs77741796	12	80,815,650	PTPRQ	Intergenic	0.054	T	C	0.09	5.83E−06
rs77595573	7	32,927,011	KBTBD2	Intronic	0.115	A	C	0.07	6.19E−06
rs78012168	3	156,150,321	KCNAB1	Intronic	0.094	A	G	0.07	7.98E−06
PWH under 45 years old
rs77741796	12	80,815,650	PTPRQ	Intergenic	0.054	T	C	0.14	2.20E−09
rs111815403	11	2,553,341	KCNQ1	Intronic	0.061	A	G	0.11	1.50E−07
rs35812497	5	108,563,812	FER;PJA2	Intergenic	0.089	A	G	0.09	3.27E−07
rs2507941	3	37,536,056	ITGA9	Synonymous	0.064	T	C	0.11	3.85E−07
rs148420952	4	171,482,271	LINC01612	Intergenic	0.051	T	C	0.12	3.94E−07
rs6762348	3	96,683,649	EPHA6	Intronic	0.058	G	A	0.11	4.42E−07
rs62263680	3	96,627,491	EPHA6	Intronic	0.057	C	T	0.12	4.50E−07
rs62262941	3	96,570,987	EPHA6	Intronic	0.057	C	T	0.11	4.80E−07
rs10847321	12	127,782,099	LINC02376	Intergenic	0.056	A	C	0.11	8.91E−07
PWH above 45 years old
rs11948504	5	166,997,147	TENM2	intronic	0.068	G	T	0.16	1.11E−06
rs9851984	3	193,090,806	ATP13A5	intronic	0.382	G	A	− 0.07	6.51E−06
rs36130341	7	343,194	FAM20C	Intergenic	0.273	A	G	0.07	7.70E−06
rs35129955	4	181,960,818	LINC00290	Intergenic	0.054	C	T	0.15	7.90E−06
rs2430722	12	15,122,111	PDE6H	Intergenic	0.255	C	T	− 0.08	1.14E−05
rs6858162	4	40,555,674	RBM47	Intronic	0.050	T	C	0.15	1.35E−05

^aAssessed by linear mixed model, adjusted for age, sex, smoking status, regular alcohol use, BMI and the first five principal components of PCA

ISSN: 1479-5876