Skip to main content

Table 1 Sociodemographic characteristics and prevalence of subclinical atherosclerosis among study participants

From: Genome-wide associated variants of subclinical atherosclerosis among young people with HIV and gene-environment interactions

Characteristics

PWH (n = 2583)

HIV-negative counterparts (n = 5321)

P valuec

 

SCA+

SCA−

P valuea

SCA+

SCA−

P valueb

Overall

940 (36.4)

1643 (63.6)

 

1516 (28.5)

3805 (71.5)

 

< 0.001d

Age (years)

  

< 0.001

  

< 0.001

< 0.001

 18–29

71 (14.1)

431 (85.9)

 

36 (3.6)

971 (96.4)

  

 30–44

195 (23.1)

651 (76.9)

 

238 (13.3)

1546 (86.7)

  

 45–59

332 (43.9)

424 (56.1)

 

557 (36.2)

980 (63.8)

  

 60–89

342 (71.4)

137 (28.6)

 

685 (69.0)

308 (31.0)

  

Male

748 (37.1)

1269 (62.9)

0.167

1214 (31.5)

2636 (68.5)

< 0.001

0.762

BMI (kg/m3) (n = 7900)

  

0.017

  

< 0.001

 < 0.001

 < 18.5

87 (33.7)

171 (66.3)

 

41 (14.2)

247 (85.8)

  

 18.5–24.0

594 (35.0)

1104 (65.0)

 

573 (23.8)

1830 (76.2)

  

 > 24

256 (41.1)

367 (58.9)

 

902 (34.3)

1728 (65.7)

  

Smoking status

  

< 0.001

  

< 0.001

< 0.001

 Never

513 (32.8)

1049 (67.2)

 

688 (22.9)

2316 (77.1)

  

 Previous

144 (46.3)

167 (53.7)

 

272 (52.2)

249 (47.8)

  

 Current

283 (39.9)

427 (60.1)

 

556 (31.0)

1240 (69.0)

  

Regular alcohol use (n = 7888)

  

< 0.001

  

< 0.001

< 0.001

 Yes

66 (55.0)

54 (45.0)

 

316 (44.1)

400 (55.9)

  

 No

874 (35.5)

1589 (64.5)

 

1196 (26.2)

3393 (73.9)

  

Dyslipidemia

  

0.095

  

< 0.001

0.487

 Yes

565 (37.8)

931 (62.2)

 

894 (32.6)

1846 (67.4)

  

 No

370 (34.6)

701 (65.4)

 

621 (24.1)

1958 (75.9)

  

Total cholesterol (mmol/L, mean ± SD)

4.80 ± 1.10

4.65 ± 1.00

< 0.001

5.19 ± 1.03

5.03 ± 0.98

< 0.001

< 0.001

LDL cholesterol (mmol/L, mean ± SD)

2.52 ± 0.81

2.44 ± 0.71

0.018

3.00 ± 0.86

2.86 ± 0.81

< 0.001

< 0.001

HDL cholesterol (mmol/L, median, IQR)

1.0 (0.9, 1.3)

1.0 (0.9, 1.2)

0.905

1.1 (0.9, 1.3)

1.1 (1.0, 1.4)

< 0.001

< 0.001

Triglycerides (mmol/L, median, IQR)

1.7 (1.2, 2.5)

1.6 (1.1, 2.4)

0.004

2.0 (1.3, 2.9)

1.7 (1.1, 2.6)

< 0.001

< 0.001

Abdominal obesity, measured as WHR (n = 7900)

439 (41.7)

614 (58.3)

< 0.001

974 (38.0)

1589 (62.0)

< 0.001

< 0.001

Hypertension

  

< 0.001

  

< 0.001

< 0.001

 Yes

307 (53.9)

262 (46.1)

 

821 (46.8)

934 (53.2)

  

 No

633 (31.4)

1381 (68.6)

 

695 (19.5)

2871 (80.5)

  

Diabetes

  

< 0.001

  

< 0.001

< 0.001

 Yes

109 (56.5)

84 (43.5)

 

307 (53.7)

265 (46.3)

  

 No

831 (34.8)

1559 (65.2)

 

1209 (25.5)

3540 (74.5)

  

Metabolic syndrome

  

< 0.001

  

< 0.001

< 0.001

 Yes

337 (45.5)

403 (54.5)

 

796 (41.0)

1147 (59.0)

  

 No

600 (32.6)

1239 (67.4)

 

716 (21.3)

2646 (78.7)

  

Baseline CD4 (cells/μl) (n = 2563)

  

0.024

    

 ≤ 200

177 (38.2)

286 (61.8)

     

 201–350

255 (40.0)

382 (60.0)

     

 > 350

500 (34.2)

963 (65.8)

     

Nadir CD4 < 200 (cells/μl) (n = 2578)

436 (37.8)

719 (62.2)

0.182

    

Years since HIV diagnosis (median, IQR)

1.2 (0.2, 4.4)

1.6 (0.3, 4.5)

0.059

    
  1. aCompared between SCA+ and SCA− among PWH, assessed by chi-square test, student t test and Mann Whitney U test in appropriate
  2. bCompared between SCA+ and SCA− among HIV-negative counterparts, assessed by chi-square test, student t test and Mann Whitney U test in appropriate
  3. cCompared between PWH and HIV-negative counterparts among those with SCA, assessed by chi-square test, student t test and Mann Whitney U test in appropriate
  4. dCompared the prevalence of SCA between PWH and HIV negative counterparts, assessed by chi-square test
  5. PWH: people with HIV; BMI: body mass index; LDL: low-density lipoprotein; HDL: high-density lipoprotein; SCA: subclinical atherosclerosis
Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us