Table 4 Genes identified in the Pain Questionnaire cohort with their tractability as drug targets using annotations from OpenTargets [109]
From: Genetic risk factors for ME/CFS identified using combinatorial analysis
Gene | Small molecule tractable | Small molecule clinical | Antibody tractable | Existing drugs | Development compounds | PDB structures |
|---|---|---|---|---|---|---|
S100PBP | 0 | 0 | 0 | 0 | 0 | 0 |
ATP9A | 0 | 0 | 1 | 0 | 0 | 0 |
KCNB1 | 0.3 | 1 | 1 | 7 | 28 | 0 |
CLOCK | 0 | 0 | 0 | 0 | 0 | 2 |
SLC15A4 | 0 | 0 | 1 | 0 | 0 | 0 |
TMEM232 | 0 | 0 | 0 | 0 | 0 | 0 |
GPC5 | 0 | 0 | 0.3 | 0 | 0 | 0 |
PHACTR2 | 0 | 0 | 0.3 | 0 | 0 | 0 |
AKAP1 | 0 | 0 | 0 | 0 | 0 | 0 |
USP6NL | 0 | 0 | 0.3 | 0 | 0 | 0 |
CDON | 0 | 0 | 0.3 | 0 | 0 | 3 |
INSR | 1 | 0.7 | 0.3 | 20 | 891 | 62 |
SULF2 | 0 | 0 | 0 | 0 | 0 | 0 |
SLC6A11 | 0.3 | 0 | 0.3 | 6 | 126 | 0 |