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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Stage-specific requirement for METTL3-dependent m6A modification during dental pulp stem cell differentiation

Fig. 6

Stage-specific NOG expression is regulated by METTL3. A The relative gene expression and mRNA expression of NOG in differentiated and undifferentiated DPSCs. B The protein expression level of NOG after METTL3 alteration determined by western blotting (n = 3). C Activation of the downstream Smad signaling pathway was evaluated by measuring the protein expression of p-Smad3, p-Smad1/5 and Smad in OM-DPSCs. D ALP activity and calcium mineralization formation in METTL3-knockdown DPSCs treated with NOG blocking antibody (n = 3). E The RUNX2 and DSPP mRNA expression levels assayed by qPCR. Significance was determined via ANOVA or Student’s t test; the data are presented as the mean ± SD (n ≥ 3). *p < 0.05. **p < 0.01. ***p < 0.001

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