Fig. 1
From: Targeting macrophages: a novel treatment strategy in solid tumors
The origin of macrophages. Macrophages originate from pluripotent hematopoietic stem cells in the bone marrow, where they differentiate into promonocytes and enter the peripheral blood. In the peripheral blood, pro-monocytes differentiate into Gr1+ inflammatory monocytes and Gr1− macrophages. Macrophages located in different tissues are called resident macrophages, such as leukodystrophy macrophages, Erythrocyte macrophages, Marginal zone macrophages, Metallophilic macrophages in the spleen, alveolar macrophages in the alveolus, Kupffer cells in the liver, tissue macrophages in the connective tissue, osteoblasts in the bone, and microglia in the central nervous system