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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Metabolomic profiles of metformin in breast cancer survivors: a pooled analysis of plasmas from two randomized placebo-controlled trials

Fig. 2

Volcano plots of detected metabolomic features and relative Spearman-based heatmap of the significant feature changes, applying untargeted and targeted metabolomics. a, c Volcano plots of detected features from untargeted (a) and targeted (c) metabolomics analyses. The beta regression coefficients of the treatment effect are plotted in the x-axis, and the − 10log (FDR-corrected P-values) in the y-axis. P-values were corrected using the Benjamini–Hochberg FDR method, considering a threshold of 0.05 for statistical significance. b, d Spearman-based heatmap of the significant feature changes detected from untargeted (b) and targeted (d) metabolomics analyses

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