Fig. 8

BI 113823 inhibited DBK-induced LX-2 hHSC proliferation, cell cycle regulation and inhibition of the PI3K signalling pathway. A DBK-induced LX-2 human HSC proliferation. B BI 113823 inhibited DBK-induced cell proliferation. C BI 113823 on normal cell proliferation. D Apoptosis. E BI 113823 on DBK-induced cell cycle progression. F Protein expression of B1R, PCNA and phosphorylation of pP70s6 kinase, pPI3K, pGSK3 and pERK. Data are representative of three independent experiments, with n = 3. p values indicated in panels, ns. not significant and significant as *p < 0.05; **p < 0.01; ***p < 0.001. One-way ANOVA and Tukey’s multiple comparison test were performed