Fig. 7

BI 113823 treatment significantly reduced LX-2 hHSC activation, proliferation, migration and contraction. A α-SMA expression. B Western blot for the protein expression of B1R, B2R, αSMA, Col1, VEGF, MCP-1 and phosphorylation of AKT. C, D Gel contraction and quantification. E Cell migration. F, G DBK-induced wound closure. Data are representative of three independent experiments, with n = 3. p values indicated in panels, ns. not significant and significant as *p < 0.05; **p < 0.01; ***p < 0.001. One-way ANOVA and Tukey’s multiple comparison test were performed