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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice

Fig. 1

BI 113823 treatment reduced CCl4-induced liver fibrosis, PH and improved survival in mice. A Liver HE staining, sirius red staining, α-SMA (red) and B1 receptor (green) IFC stain and their quantification. B Hydroxyproline assay for total collagen in liver; C liver:bodyweight ratio; D bodyweight changes; E changes in portal vein pressure; and F survival rate. G The expression of B1 receptor mRNA in CCl4 mice livers; H Western blot for the protein expression of B1R, Gly-B2R, B2R, GAPDH in CCl4 mice livers. Values are mean ± SEM, n = 7–8. p values indicated in panels, ns. not significant and significant as *p < 0.05; **p < 0.01; ***p < 0.001. A–E, G–H One-way ANOVA and Tukey’s multiple comparison test were performed. F Survival curves were analyzed by the nonparametric Mantel-Cox test

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