Fig. 2

Calcitriol alleviates muscle weakness in HSA^LR mice. (a) WT and HSA^LR mice were treated with calcitriol as indicated. Vitamin D level of plasma from each group were analyzed. Mean and SEM (n = 8, 8 and 8 in WT, DM1 0 µg/kg/d and DM1 1 µg/kg/d, respectively) are indicated. (b–d) Calcitriol induced partial recovery from the muscle weakness occurring in the HSA^LR mice. The time that the mice stay on the rotarod (b), the grip strength (c) and the time that the mice hang on the wire mesh (d) of each group was recorded. Mean and SEM (n = 9, 9 and 8 in WT, DM1 0 µg/kg/d and DM1 1 µg/kg/d, respectively) are indicated. *p < 0.05, **p < 0.01 and ***p < 0.001 by one-way ANOVA followed by Turkey multiple comparison correction (a), and by two-way ANOVA followed by Turkey multiple comparison correction (b–d)