Fig. 6

GPT2 up-regulation altered the oncogenicity in ccRCC cells. A qRT-PCR assay revealed GPT2 was up-regulated in ccRCC samples. B The mRNA and protein expression levels of GPT2 were up-regulated in ccRCC cell lines. C The receiver operating characteristic (ROC) curve of GPT2 in the TCGA-KIRC cohort. D High GPT2 expression level predicted worse OS, DSS and PFI in the TCGA-KIRC cohort. E Kaplan–Meier survival curves of patients stratified by GPT2 expression level in the NJMU ccRCC cohort 2 (N = 180). F Cell growth after GPT2 knockdown detected by CCK-8 assay. B Colony formation assay of RCC cells after GPT2 knockdown. H Lactate concentrations, glucose consumption rates and ATP concentration of 786-O cells after GPT2 knockdown. I Lactate concentrations, glucose consumption rates and ATP concentration of Caki-1 cells after GPT2 knockdown. (**: P < 0.05)