Fig. 3

Knockdown SPTBN1 promoted inhibited the proliferation of ccRCC cells in vitro and in vivo. A Cell growth after knockdown or overexpression SPTBN1 at indicated time points. B Colony formation assay of RCC cells after knockdown or overexpression SPTBN1. C Cell cycle distribution in control, knockdown SPTBN1 and overexpression SPTBN1 RCC cells. D Knockdown SPTBN1 promoted ccRCC cell proliferation in vivo. Tumor volume was monitored every other day. E IHC of PCNA, and Ki-67 derived from shSPTBN1 786-O cells. (**: P < 0.05)