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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: C/D box small nucleolar RNA SNORD104 promotes endometrial cancer by regulating the 2ʹ-O-methylation of PARP1

Fig. 5

SNORD104 stabilizes PARP1 mRNA via 2ʹ-O-methylation. (A) Schematic diagram of RTL-P experiment. B 2ʹ-O-methylated PARP1 mRNA levels in SNORD104-knockdown cells. C 2ʹ-O-methylated PARP1 mRNA levels in SNORD104-overexpressing HECB1 cells. D 2ʹ-O-methylated PARP1 mRNA levels in SNORD104-overexpressing HECB1 cells with FBL knockdown. E, F PARP1 protein levels in SNORD104-overexpressing HECB1 cells with FBL knockdown. G PARP1 mRNA stability in SNORD104-knockdown cells treated with Act D (5 μg/ml). H PARP1 mRNA stability in SNORD104-overexpressing cells. I PARP1 mRNA stability in FBL-knockdown cells. *P < 0.05

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Journal of Translational Medicine

ISSN: 1479-5876

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