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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Smooth muscle cell fate decisions decipher a high-resolution heterogeneity within atherosclerosis molecular subtypes

Fig. 5

Establishment of three molecular subtypes with heterogeneous illness severity by MOVICS analysis. A Determination of optimal cluster number through calculating CPI (blue line) and Gaps-statistics (red line) in AS cohort. B Consensus heatmap based on outcomes from 10 multi-omics integrative clustering approaches with subtype number of 3 showing perfect diagonal rectangle. C Comprehensive heatmap based on consensus across ten algorithms with upregulated and downregulated SCFDS. D Agreement of predicted three subtypes with the severity of coronary stenosis in AS cohort. E Comparison of our novel subtype and the severity of coronary stenosis in AS patients. (Fisher exact test; P < 0.05). F Alluvial diagram presenting the flow distribution of AS severity between different subtypessubtypes. G The distribution of hallmark signatures enrichment score among three subtypes. H The distribution of top subtype-specific activated pathways. I The most predominant upstream regulators of each subtype

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