Fig. 4

LAMB1 was upregulated in cHCC-ICC. A Volcano plot analysis of 1120 differential genes expressed between MAP^HDVI and MAP^Epo tumors. The criteria of analysis were Log₂FC ≥ 1 or ≤ -1, p < 0.05. Genes that upregulated in MAP^Epo tumors were shown in blue plots, while genes that upregulated in MAP^HDVI tumors were in red plots. B Venn gram presented 73 overlapping genes between 552 upregulated genes in MAP^Epo tumors and 588 upregulated genes in the GSE35306 data set. C GO and D KEGG analysis of 73 genes obtained in Fig. 4B. E The expression of LAMB1 gene in human ICC, HCC, and cHCC-ICC from GSE35306, GSE84073, and GSE15765 datasets