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Table 2 Multivariable analysis of the prognostic value of radiogenomic signatures and other clinical factors

From: CT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study

 

Radiogenomics dataset

Imaging test dataset 1

Imaging test dataset 2

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Sex:(M vs. F)

1.33 (0.87–2.05)

0.17

1.48 (1.03–2.14)

0.03

1.14 (0.5–2.65)

0.75

CEA:(Abnormal vs. Normal)

1.95 (1.29–2.96)

0.0014

1.51 (1.5–2.19)

0.025

1 (0.42–2.37)

0.98

Tumour grade: (Low vs. Middle + High)

1.22 (0.66–2.25)

0.52

1.94 (0.94–4)

0.07

1.74 (0.72–4.23)

0.22

TNM stage: (I + II vs. III + IV)

4.29 (2.5–7.38)

 < 0.001

2.74 (1.84–4.1)

 < 0.001

2.24 (0.81–6.2)

0.12

Radiogenomics groups: (High risk vs. Low risk)

1.59 (1.03–2.45)

0.034

1.42 (1–2.02)

0.05

2.78 (1.21–6.34)

0.01