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Table 1 The list of 35 DEPs in expression pattern clustering analysis after DBS intervention

From: Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model

Protein ID

Gene name

Protein name

Cluster

Membership

A9UMV9

Ndufa7

Complex I-B14.5a

Cluster1

0.9920

P62329

tmsb4x

Thymosin beta-4

Cluster1

0.9918

F1LT49

Lrrc47

Leucine-rich repeat-containing 47

Cluster1

0.9916

Q6MG60

Ddah2*

N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

Cluster1

0.9891

D4ABT8

Hnrnpul2b

Heterogeneous nuclear ribonucleoprotein U-like 2

Cluster1

0.9971

B0K020

Cisd1

CDGSH iron-sulfur domain-containing protein 1

Cluster1

0.9975

Q63524

Tmed2*

Transmembrane emp24 domain-containing protein 2

Cluster1

0.9882

P10687

Plcb1b

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Cluster1

0.9976

G3V864

plppr4

Phospholipid phosphatase-related protein type 4

Cluster1

0.9873

D4A5L9

LOC690675

Similar to cytochrome c, somatic

Cluster1

0.9985

P13668

Stmn1

Stathmin

Cluster1

0.9790

D3ZC89

Fam114a2*

Family with sequence similarity 114, member A2

Cluster1

0.9785

Q6P7Q4

Glo1b

Lactoylglutathione lyase

Cluster1

0.9784

Q5RKG9

Eif4b

Eukaryotic translation initiation factor 4B

Cluster1

0.9953

A0A0H2UHA0

Ppp1r2*

Protein phosphatase inhibitor 2

Cluster1

0.9942

F1M4R7

Cspg5

Chondroitin sulfate proteoglycan 5

Cluster1

0.9465

P20788

Uqcrfs1

Cytochrome b-c1 complex subunit Rieske, mitochondrial

Cluster1

0.9762

D3ZU64

Vps37b

VPS37B subunit of ESCRT-I

Cluster1

0.9796

Q9WV48

Shank1*ab

SH3 and multiple ankyrin repeat domains protein 1

Cluster1

0.6440

F1M820

Sorbs1

Sorbin and SH3 domain-containing protein 1

Cluster1

0.9929

A0A0G2JSM7

Add1

Adducin 1 (Alpha), isoform CRA_b

Cluster1

0.9942

G3V9G1

Adcy5b

Adenylate cyclase type 5

Cluster2

0.9056

D3ZAP9

Gpd1l

Glycerol-3-phosphate dehydrogenase [NAD( +)]

Cluster2

0.8912

Z4YNP1

Celf2b

CUGBP Elav-like family member 2

Cluster2

0.9632

Q3S4A5

Arfgap1

ADP-ribosylation factor GTPase activating protein 1 brain isoform

Cluster2

0.9142

Q5MJ12

Fbxl16*a

F-box/LRR-repeat protein 16

Cluster2

0.9737

B0LPN4

Ryr2

Ryanodine receptor 2

Cluster2

0.9860

D3ZWG2

Rgs7b

Regulator of G-protein-signaling 7

Cluster2

0.8349

Q62991

Scfd1*

Sec1 family domain-containing protein 1

Cluster2

0.8875

F1LMR7

Dpp6b

Dipeptidyl aminopeptidase-like protein 6

Cluster2

0.7682

D3ZMJ7

Wnk2

Non-specific serine/threonine protein kinase

Cluster2

0.9916

Q63525

Nudc

Nuclear migration protein nudC

Cluster2

0.9241

A0A0G2JTD7

Clasp1*b

Cytoplasmic linker-associated protein 1

Cluster2

0.8811

D3ZT36

Adam23

ADAM metallopeptidase domain 23

Cluster2

0.8691

Q8CGU4

Agap2b

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

Cluster2

0.9909

  1. *Proteins could be normalized after HF-DBS intervention that also belong ro the 56 DEPs obtained from VPA versus saline batches
  2. a20 hub DEPs from 56 DEPs
  3. bSFARI database of ASD
  4. DEPs differentially expressed proteins