Fig. 6

A GO analysis of the significant proteins on their biological process, B molecular function and C cellular component. Yellow indicates the up-regulated and green the down-regulated terms. Bubble chart of the KEGG enrichment analysis. The x-axis is the enrichment score and the y-axis is the pathway terms. The size of the bubbles reflects the number of differentially expressed proteins. The larger the bubble, the greater the number of differentially expressed proteins. The lower the P-value, the higher the significance of the KEGG pathway enrichment. D Enrichment pathways screened among total differentially expressed proteins. E Enriched pathways screened among up-regulated proteins. F Enriched pathways screened among down-regulated proteins. G PPI of 20 hub proteins. In hub protein analysis, the darker the color, the higher the score. KEGG Kyoto Encyclopedia of Genes and Genomes, GO Gene Ontology, PPI protein-protein interaction