Fig. 4

When HF-DBS was turned off for 7 days (Day 36), the effect of HF-DBS on repetitive behavior was weakened. A Total distance travelled by test rat on day 36. B Number of self-grooming behavior on day 36. C Duration of self-grooming behavior on day 36. One-way ANOVA with post-hoc Tukey’s test, ^*p < 0.05 vs. saline; ^#p < 0.05 vs. VPA. HF-DBS reversed the repetitive/stereotypic-like activities in marble burying test: D Number of marbles buried. Data are shown as mean with SD. Two-way repeated ANOVA with post-hoc Bonferroni test, ^**p < 0.01 vs. saline; ^***p < 0.001 vs. saline; ^##p < 0.01 vs. VPA; ^###p < 0.001 vs. VPA. E Number of marbles buried on day 36. Data are shown as mean with SD. one-way ANOVA with post-hoc Tukey's test, ^***p < 0.001 vs. Saline. There is no significant effect on spatial learning ability and cognitive rigidity in the VPA-exposed offspring. F Number of total corner visits in phase 1. G Lick dutation of all corners in phase 1. H Number of total corner visits in phase 2. I Ratio of the number of correct corner visits to the number of total corner visits in phase 3. J Ratio of the number of correct corner visits to the number of total corner visits in phase 4. Data are shown as mean with SD. Ono-way ANOVA with post-hoc Tukey's test, ^* p < 0.05 vs. saline; ^** p < 0.01 vs. saline; ^*** p < 0.001 vs. saline. K Representative marbles buried maps of marbel burying test on day 18